Joint Analysis of Genetic Correlation, Mendelian Randomization and Colocalization Highlights the Bi-Directional Causal Association Between Hypothyroidism and Primary Biliary Cirrhosis

Joint Analysis of Genetic Correlation, Mendelian Randomization and Colocalization Highlights the Bi-Directional Causal Association Between Hypothyroidism and Primary Biliary Cirrhosis

Background: Hypothyroidism and primary biliary cirrhosis (PBC) are often co-existed in observational epidemiological studies. However, the causal relationship between them remains unclear.Methods: Genetic correlation, Mendelian randomization (MR) and colocalization analysis were combined to assess t...

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Bibliographic Details
Main Authors: Yanjun Wang, Ping Guo, Yanan Zhang, Lu Liu, Ran Yan, Zhongshang Yuan, Yongfeng Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Genetics
Subjects:
hypothyroidism
primary biliary cirrhosis
causal association
genome-wide association study
mendelian randomization
genetic correlation
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.753352/full

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