Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation

Molecular Dynamics Simulations and Dynamic Network Analysis Reveal the Allosteric Unbinding of Monobody to H-Ras Triggered by R135K Mutation

Ras proteins, as small GTPases, mediate cell proliferation, survival and differentiation. Ras mutations have been associated with a broad spectrum of human cancers and thus targeting Ras represents a potential way forward for cancer therapy. A recently reported monobody NS1 allosterically disrupts t...

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Bibliographic Details
Main Authors: Duan Ni, Kun Song, Jian Zhang, Shaoyong Lu
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:International Journal of Molecular Sciences
Subjects:
H-Ras
molecular dynamics (MD) simulations
allosteric pathway
allosteric network
allostery
R135K mutation
Online Access:https://www.mdpi.com/1422-0067/18/11/2249

Internet

https://www.mdpi.com/1422-0067/18/11/2249

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