GlyT2-dependent preservation of MECP2-expression in inhibitory neurons improves early respiratory symptoms but does not rescue survival in a mouse model of Rett syndrome

GlyT2-dependent preservation of MECP2-expression in inhibitory neurons improves early respiratory symptoms but does not rescue survival in a mouse model of Rett syndrome

Mutations in methyl-CpG-binding protein 2 (MECP2) gene have been shown to manifest in a neurodevelopmental disorder that is called Rett syndrome. A typical problem that occurs during development is a disturbance of breathing. To address the role of inhibitory neurons, we generated a mouse line that...

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Bibliographic Details
Main Authors: Swen Hülsmann, Guillaume Mesuret, Julia Dannenberg, Mauricio Arnoldt, Marcus Niebert
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Physiology
Subjects:
Apnea
Hypoventilation
Hypoxia, Brain
mouse models of rett syndrome
regulation of breathing
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00385/full

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