Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection.

Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection.

HIV-1 infection is complicated by high rates of opportunistic infections against which specific antibodies contribute to immune defense. Antibody function depends on somatic hypermutation (SHM) of variable regions of immunoglobulin heavy chain genes (VH-D-J). We characterized the frequency of SHM in...

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Bibliographic Details
Main Authors: Elisabeth Bowers, Ronald W Scamurra, Anil Asrani, Lydie Beniguel, Samantha MaWhinney, Kathryne M Keays, Joseph R Thurn, Edward N Janoff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3883639?pdf=render

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