Analysis of literature data on the relationship between vitamin D deficiency and type 1 diabetes mellitus

• Main Authors: Victoriia Fylymonenko, Liubov Galuzinska, Tetiana Briukhanova, Olena Chumak, Olena Yatsenko
• Format: Article
• Language: English
• Published: PC Technology Center 2021-06-01
• Series: ScienceRise: Biological Science
• Subjects: vitamin d; type 1 diabetes mellitus; immunomodulatory and anti-inflammatory activity; pancreatic β cells
• Online Access: http://journals.uran.ua/sr_bio/article/view/235426
• ISSN: 2519-8017; 2519-8025

Type 1 diabetes mellitus is a chronic autoimmune disease in which genetic predisposition and environmental factors play a major role. Vitamin D deficiency is becoming a pandemic in the world and is observed in type 1 diabetes mellitus. The aim. Analytical review of available literature data on the relationship of vitamin D deficiency with the development and course of type 1 diabetes mellitus. Materials and methods. Analysis of open sources of scientific literature. Results and discussion. Clinical observations and experimental studies show that vitamin D deficiency is one of the risk factors for the development of type 1 diabetes, and is a consequence of this disease. The status of vitamin D in the body is determined not only by the intake of vitamin from the outside, but also by the activity of tissue transport and metabolism systems, which have a high degree of polymorphism. Numerous studies show the positive effect of the use of vitamin D preparations in the prevention and treatment of type 1 diabetes mellitus. However, there are works in which there is no protective effect. Conclusions. Thus, the optimization of the status of vitamin D in the body is a promising measure to prevent the development of type 1 diabetes and facilitate its course, but requires further research.