Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

It is recognized that cellular senescence is triggered by DNA damage as a protective mechanism against tumorigenesis. Here the authors show that DNA single-strand breaks of oxidative origin can induce a transient senescent state followed by the emergence of clonal transformed cells.

Bibliographic Details
Main Authors: Joe Nassour, Sébastien Martien, Nathalie Martin, Emeric Deruy, Elisa Tomellini, Nicolas Malaquin, Fatima Bouali, Laure Sabatier, Nicolas Wernert, Sébastien Pinte, Eric Gilson, Albin Pourtier, Olivier Pluquet, Corinne Abbadie
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10399
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spelling doaj-e4ec0071870844e6bdd95abc3f6201342021-05-11T11:20:29ZengNature Publishing GroupNature Communications2041-17232016-01-017111610.1038/ncomms10399Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cellsJoe Nassour0Sébastien Martien1Nathalie Martin2Emeric Deruy3Elisa Tomellini4Nicolas Malaquin5Fatima Bouali6Laure Sabatier7Nicolas Wernert8Sébastien Pinte9Eric Gilson10Albin Pourtier11Olivier Pluquet12Corinne Abbadie13Univ. Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Targeted TherapiesUniv. Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Targeted TherapiesUniv. Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Targeted TherapiesUniv. Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Targeted TherapiesUniv. Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Targeted TherapiesUniv. Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Targeted TherapiesUniv. Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Targeted TherapiesCommissariat à l'Energie Atomique (CEA), Laboratoire de Radiobiologie et Oncologie (LRO), 18 route du Panorama - BP6Institute of Pathology, University of BonnUniv. Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Targeted TherapiesInstitute for Research on Cancer and Aging, Nice (IRCAN), University of Nice Sophia Antipolis, CNRS, UMR7284, INSERM U108, Faculty of Medecine of Nice; CHU of NiceUniv. Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Targeted TherapiesUniv. Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Targeted TherapiesUniv. Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Targeted TherapiesIt is recognized that cellular senescence is triggered by DNA damage as a protective mechanism against tumorigenesis. Here the authors show that DNA single-strand breaks of oxidative origin can induce a transient senescent state followed by the emergence of clonal transformed cells.https://doi.org/10.1038/ncomms10399
collection DOAJ
language English
format Article
sources DOAJ
author Joe Nassour
Sébastien Martien
Nathalie Martin
Emeric Deruy
Elisa Tomellini
Nicolas Malaquin
Fatima Bouali
Laure Sabatier
Nicolas Wernert
Sébastien Pinte
Eric Gilson
Albin Pourtier
Olivier Pluquet
Corinne Abbadie
spellingShingle Joe Nassour
Sébastien Martien
Nathalie Martin
Emeric Deruy
Elisa Tomellini
Nicolas Malaquin
Fatima Bouali
Laure Sabatier
Nicolas Wernert
Sébastien Pinte
Eric Gilson
Albin Pourtier
Olivier Pluquet
Corinne Abbadie
Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
Nature Communications
author_facet Joe Nassour
Sébastien Martien
Nathalie Martin
Emeric Deruy
Elisa Tomellini
Nicolas Malaquin
Fatima Bouali
Laure Sabatier
Nicolas Wernert
Sébastien Pinte
Eric Gilson
Albin Pourtier
Olivier Pluquet
Corinne Abbadie
author_sort Joe Nassour
title Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
title_short Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
title_full Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
title_fullStr Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
title_full_unstemmed Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
title_sort defective dna single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-01-01
description It is recognized that cellular senescence is triggered by DNA damage as a protective mechanism against tumorigenesis. Here the authors show that DNA single-strand breaks of oxidative origin can induce a transient senescent state followed by the emergence of clonal transformed cells.
url https://doi.org/10.1038/ncomms10399
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