A novel prognostic index—neutrophil times γ-glutamyl transpeptidase to lymphocyte ratio (NγLR) predicts outcome for patients with hepatocellular carcinoma

Abstract Clinical outcomes of patients with hepatocellular carcinoma (HCC) are highly variable. This study aims to identify and validate a simple, readily available, and objective prognostic index for the management of HCC. Data from 724 HCC patients undergoing curative resection were evaluated and...

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Main Authors: Jun Li, Yan Liao, Liya Suo, Pengpeng Zhu, Xinhuang Chen, Wei Dang, Minjun Liao, Liling Qin, Weijia Liao
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-09696-y
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spelling doaj-e4e4e843ef674f9fadf9f38b7ad2a2d42020-12-08T01:52:52ZengNature Publishing GroupScientific Reports2045-23222017-08-017111110.1038/s41598-017-09696-yA novel prognostic index—neutrophil times γ-glutamyl transpeptidase to lymphocyte ratio (NγLR) predicts outcome for patients with hepatocellular carcinomaJun Li0Yan Liao1Liya Suo2Pengpeng Zhu3Xinhuang Chen4Wei Dang5Minjun Liao6Liling Qin7Weijia Liao8Laboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityLaboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityLaboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityLaboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityLaboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityLaboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityGuangxi Medical UniversityLaboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityLaboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityAbstract Clinical outcomes of patients with hepatocellular carcinoma (HCC) are highly variable. This study aims to identify and validate a simple, readily available, and objective prognostic index for the management of HCC. Data from 724 HCC patients undergoing curative resection were evaluated and randomly divided into two cohorts for building and validating the prognostic index. A best model, NγLR = (neutrophil count [109/L] × γ-glutamyl transpeptidase [U/L]) /(lymphocyte count [109/L] × U/L), was selected. An optimal cut-off value of 103.6 for NγLR stratified patients into high NγLR (>103.6) and low NγLR (≤103.6) groups. NγLR > 103.6 was closely associated with HCC malignant characteristics. Elevated NγLR predicted a worse overall survival (OS) and progression-free survival (PFS) for HCC patients and remained an independent predictor for both types of survival. Moreover, early recurrence rates in patients with NγLR > 103.6 were higher than that in patients with NγLR ≤ 103.6 (P < 0.0001). NγLR was an important independent predictor of survival for HCC patients and might be a new promising method to identify patients at different risks of early recurrence and survival after curative resection.https://doi.org/10.1038/s41598-017-09696-y
collection DOAJ
language English
format Article
sources DOAJ
author Jun Li
Yan Liao
Liya Suo
Pengpeng Zhu
Xinhuang Chen
Wei Dang
Minjun Liao
Liling Qin
Weijia Liao
spellingShingle Jun Li
Yan Liao
Liya Suo
Pengpeng Zhu
Xinhuang Chen
Wei Dang
Minjun Liao
Liling Qin
Weijia Liao
A novel prognostic index—neutrophil times γ-glutamyl transpeptidase to lymphocyte ratio (NγLR) predicts outcome for patients with hepatocellular carcinoma
Scientific Reports
author_facet Jun Li
Yan Liao
Liya Suo
Pengpeng Zhu
Xinhuang Chen
Wei Dang
Minjun Liao
Liling Qin
Weijia Liao
author_sort Jun Li
title A novel prognostic index—neutrophil times γ-glutamyl transpeptidase to lymphocyte ratio (NγLR) predicts outcome for patients with hepatocellular carcinoma
title_short A novel prognostic index—neutrophil times γ-glutamyl transpeptidase to lymphocyte ratio (NγLR) predicts outcome for patients with hepatocellular carcinoma
title_full A novel prognostic index—neutrophil times γ-glutamyl transpeptidase to lymphocyte ratio (NγLR) predicts outcome for patients with hepatocellular carcinoma
title_fullStr A novel prognostic index—neutrophil times γ-glutamyl transpeptidase to lymphocyte ratio (NγLR) predicts outcome for patients with hepatocellular carcinoma
title_full_unstemmed A novel prognostic index—neutrophil times γ-glutamyl transpeptidase to lymphocyte ratio (NγLR) predicts outcome for patients with hepatocellular carcinoma
title_sort novel prognostic index—neutrophil times γ-glutamyl transpeptidase to lymphocyte ratio (nγlr) predicts outcome for patients with hepatocellular carcinoma
publisher Nature Publishing Group
series Scientific Reports
issn 2045-2322
publishDate 2017-08-01
description Abstract Clinical outcomes of patients with hepatocellular carcinoma (HCC) are highly variable. This study aims to identify and validate a simple, readily available, and objective prognostic index for the management of HCC. Data from 724 HCC patients undergoing curative resection were evaluated and randomly divided into two cohorts for building and validating the prognostic index. A best model, NγLR = (neutrophil count [109/L] × γ-glutamyl transpeptidase [U/L]) /(lymphocyte count [109/L] × U/L), was selected. An optimal cut-off value of 103.6 for NγLR stratified patients into high NγLR (>103.6) and low NγLR (≤103.6) groups. NγLR > 103.6 was closely associated with HCC malignant characteristics. Elevated NγLR predicted a worse overall survival (OS) and progression-free survival (PFS) for HCC patients and remained an independent predictor for both types of survival. Moreover, early recurrence rates in patients with NγLR > 103.6 were higher than that in patients with NγLR ≤ 103.6 (P < 0.0001). NγLR was an important independent predictor of survival for HCC patients and might be a new promising method to identify patients at different risks of early recurrence and survival after curative resection.
url https://doi.org/10.1038/s41598-017-09696-y
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