Hybrid Modeling for Simultaneous Prediction of Flux, Rejection Factor and Concentration in Two-Component Crossflow Ultrafiltration

Ultrafiltration is a powerful method used in virtually every pharmaceutical bioprocess. Depending on the process stage, the product-to-impurity ratio differs. The impact of impurities on the process depends on various factors. Solely mechanistic models are currently not sufficient to entirely descri...

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Bibliographic Details
Main Authors: Maximilian Krippl, Ignasi Bofarull-Manzano, Mark Duerkop, Astrid Dürauer
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Processes
Subjects:
Online Access:https://www.mdpi.com/2227-9717/8/12/1625

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