Angiopoietin-Like Protein 4 Overexpression in Visceral Adipose Tissue from Obese Subjects with Impaired Glucose Metabolism and Relationship with Lipoprotein Lipase

Angiopoietin-Like Protein 4 Overexpression in Visceral Adipose Tissue from Obese Subjects with Impaired Glucose Metabolism and Relationship with Lipoprotein Lipase

Angiopoietin-like protein 4 (ANGPTL4) regulates lipid partitioning by inhibiting circulating and tissue lipoprotein lipase (LPL); ANGPTL4 loss-of-function variants improve insulin sensitivity and reduce type 2 diabetes (T2D) risk with mechanisms partially unknown. This study was designed to explore...

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Bibliographic Details
Main Authors: Ilaria Barchetta, Caterina Chiappetta, Valentina Ceccarelli, Flavia Agata Cimini, Laura Bertoccini, Melania Gaggini, Claudio Di Cristofano, Gianfranco Silecchia, Andrea Lenzi, Frida Leonetti, Marco Giorgio Baroni, Amalia Gastaldelli, Maria Gisella Cavallo
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
ANGPTL4
lipoprotein lipase
lipids
adipose tissue
adipocyte
diabetes
Online Access:https://www.mdpi.com/1422-0067/21/19/7197

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