Prospective validation of candidate SNPs of VEGF/VEGFR pathway in metastatic colorectal cancer patients treated with first-line FOLFIRI plus bevacizumab.

Prospective validation of candidate SNPs of VEGF/VEGFR pathway in metastatic colorectal cancer patients treated with first-line FOLFIRI plus bevacizumab.

The potential impact of different SNPs of VEGF/VEGFR pathway on the clinical outcome of mCRC patients receiving bev-containing regimens has been investigated in retrospective experiences with contrasting results. We previously reported the association of VEGFA rs833061 C/T variants with PFS in metas...

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Main Authors: Fotios Loupakis, Chiara Cremolini, Dongyun Yang, Lisa Salvatore, Wu Zhang, Takeru Wakatsuki, Pierre Bohanes, Marta Schirripa, Leonor Benhaim, Sara Lonardi, Carlotta Antoniotti, Giuseppe Aprile, Francesco Graziano, Annamaria Ruzzo, Sara Lucchesi, Monica Ronzoni, Ferdinando De Vita, Giuseppe Tonini, Alfredo Falcone, Heinz-Josef Lenz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3701556?pdf=render

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