Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways

Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways

In <i>Drosophila</i>, endoplasmic reticulum (ER) stress activates the protein kinase R-like endoplasmic reticulum kinase (dPerk). dPerk can also be activated by defective mitochondria in fly models of Parkinson’s disease caused by mutations in <i>pink1</i> or <i>parkin&...

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Bibliographic Details
Main Authors: Rebeka Popovic, Ivana Celardo, Yizhou Yu, Ana C. Costa, Samantha H. Y. Loh, L. Miguel Martins
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Drosophila</i>
<i>Drosophila</i> protein kinase RNA (PKR)-like ER kinase (dPerk)
ER stress
unfolded protein response
activating transcription factor 4 (ATF4)
Online Access:https://www.mdpi.com/1422-0067/22/9/4598

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https://www.mdpi.com/1422-0067/22/9/4598

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