Regulation of activity-dependent neuroprotective protein (ADNP) by the NO-cGMP pathway in the hippocampus during kainic acid-induced seizure

Regulation of activity-dependent neuroprotective protein (ADNP) by the NO-cGMP pathway in the hippocampus during kainic acid-induced seizure

Activity-dependent neuroprotective protein (ADNP) is widely distributed in the cytoplasm of neurons and astrocytes of the hippocampus. Kainic acid (KA)-induced seizures increases neuronal nitric oxide synthase (nNOS) in neurons and inducible NOS (iNOS) in glia cells which coincides with a reduction...

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Bibliographic Details
Main Authors: Anna S. Cosgrave, Jennifer S. McKay, Vivien Bubb, Richard Morris, John P. Quinn, Thimmasettappa Thippeswamy
Format: Article
Language:English
Published: Elsevier 2008-06-01
Series:Neurobiology of Disease
Subjects:
Epilepsy
Kainic acid
Neuroprotection
ADNP
Nitric oxide synthase blockers
cGMP
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000211

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