Outcomes of Definitive Chemoradiotherapy for Stage IVa (T4b vs. N4) Esophageal Squamous Cell Carcinoma based on the Japanese Classification System: A Retrospective Single-Center Study

• Main Authors: Yuki Wada, Akira Anbai, Noriko Takagi, Satoshi Kumagai, Eriko Okuyama, Hiroshi Nanjo, Yusuke Sato, Satoru Motoyama, Manabu Hashimoto
• Format: Article
• Language: English
• Published: MDPI AG 2021-12-01
• Series: Cancers
• Subjects: esophageal squamous cell carcinoma; definitive chemoradiation therapy; external beam radiation therapy; locally advanced esophageal cancer
• Online Access: https://www.mdpi.com/2072-6694/13/1/8

The differences in prognoses or progression patterns between T4b non-N4 and non-T4b N4 esophageal squamous cell carcinoma post chemoradiotherapy (CRT) is unclear. This study compared the outcomes of CRT for stage IVa esophageal squamous cell carcinoma according to T/N factors. We retrospectively identified 66 patients with stage IVa esophageal squamous cell carcinoma who underwent definitive CRT at our center between January 2009 and March 2013. The treatment outcomes, i.e., progression patterns, prognostic factors, and toxicities based on version 5.0 of the National Cancer Institute Common Terminology Criteria for Adverse Events, were studied. The patients (56 men and 10 women) had a median age of 67 (range: 37–87) years. The T/N classifications were T4b non-N4 (28/66), non-T4b N4 (24/66), and T4b N4 (14/66). Objective response was achieved in 57 patients (86.4%, (95% confidence interval, 74.6–94.1%)). There were no significant differences between the T/N groups in terms of overall survival, progression-free survival, and progression pattern. We found no significant differences in prognoses or progression patterns among patients with T4b non-N4, non-T4b N4, and T4b N4 esophageal squamous cell carcinoma. Thus, it seems impractical to modify CRT regimens based on T/N factors.