Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis model

Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis model

The effects of pear vinegar (PV), which was specially brewed for enhanced galacturonic acid content, on the DSS-induced ulcerative colitis (UC) mouse model were evaluated. PV improved clinical symptoms, colon inflammation, and histological tissue injury in the DSS-induced acute UC mouse model. Moreo...

Full description

Bibliographic Details
Main Authors: Takashi Wakuda, Kazuo Azuma, Hiroyuki Saimoto, Shinsuke Ifuku, Minoru Morimoto, Ichiro Arifuku, Masahito Asaka, Takeshi Tsuka, Tomohiro Imagawa, Yoshiharu Okamoto, Tomohiro Osaki, Saburo Minami
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Journal of Functional Foods
Subjects:
Pear vinegar
Inflammatory bowel disease
Functional food
Dextran sodium sulfate
Mice
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464612001569
id doaj-e4caf50e8fc84387aa2bc57de6f997c7
record_format Article
spelling doaj-e4caf50e8fc84387aa2bc57de6f997c72021-04-29T04:40:47ZengElsevierJournal of Functional Foods1756-46462013-01-0151516523Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis modelTakashi Wakuda0Kazuo Azuma1Hiroyuki Saimoto2Shinsuke Ifuku3Minoru Morimoto4Ichiro Arifuku5Masahito Asaka6Takeshi Tsuka7Tomohiro Imagawa8Yoshiharu Okamoto9Tomohiro Osaki10Saburo Minami11Faculty of Agriculture, Tottori University, Tottori 680-8553, JapanFaculty of Agriculture, Tottori University, Tottori 680-8553, JapanGraduate School of Engineering, Tottori University, Tottori 680-8550, JapanGraduate School of Engineering, Tottori University, Tottori 680-8550, JapanResearch Center for Bioscience and Technology, Tottori University, Tottori 680-8550, JapanDepartment of Applied Biotechnology, Food Developing Laboratory, Tottori Institute of Industrial Technology, Sakaiminato, Tottori 684-0041, JapanAON Chemical Corporation, Tottori 689-1112, JapanFaculty of Agriculture, Tottori University, Tottori 680-8553, JapanFaculty of Agriculture, Tottori University, Tottori 680-8553, JapanFaculty of Agriculture, Tottori University, Tottori 680-8553, JapanFaculty of Agriculture, Tottori University, Tottori 680-8553, Japan; Corresponding author. Address: Department of Veterinary Clinical Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. Tel./fax: +81 857 31 5434.Faculty of Agriculture, Tottori University, Tottori 680-8553, JapanThe effects of pear vinegar (PV), which was specially brewed for enhanced galacturonic acid content, on the DSS-induced ulcerative colitis (UC) mouse model were evaluated. PV improved clinical symptoms, colon inflammation, and histological tissue injury in the DSS-induced acute UC mouse model. Moreover, PV suppressed inflammation due to acute UC by suppressing the myeloperoxidase (MPO)-mediated activation of inflammatory cells such as leukocytes and decreasing the serum concentration of IL-6. Our results demonstrated the protective action of PV in the DSS-induced acute UC mouse model. On the other hand, commercial apple vinegar did not show a protective effect in the DSS-induced acute UC mouse model. Our findings indicate that PV may act as a new functional food for inflammatory bowel disease patients.http://www.sciencedirect.com/science/article/pii/S1756464612001569Pear vinegarInflammatory bowel diseaseFunctional foodDextran sodium sulfateMice
collection DOAJ
language English
format Article
sources DOAJ
author Takashi Wakuda
Kazuo Azuma
Hiroyuki Saimoto
Shinsuke Ifuku
Minoru Morimoto
Ichiro Arifuku
Masahito Asaka
Takeshi Tsuka
Tomohiro Imagawa
Yoshiharu Okamoto
Tomohiro Osaki
Saburo Minami
spellingShingle Takashi Wakuda
Kazuo Azuma
Hiroyuki Saimoto
Shinsuke Ifuku
Minoru Morimoto
Ichiro Arifuku
Masahito Asaka
Takeshi Tsuka
Tomohiro Imagawa
Yoshiharu Okamoto
Tomohiro Osaki
Saburo Minami
Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis model
Journal of Functional Foods
Pear vinegar
Inflammatory bowel disease
Functional food
Dextran sodium sulfate
Mice
author_facet Takashi Wakuda
Kazuo Azuma
Hiroyuki Saimoto
Shinsuke Ifuku
Minoru Morimoto
Ichiro Arifuku
Masahito Asaka
Takeshi Tsuka
Tomohiro Imagawa
Yoshiharu Okamoto
Tomohiro Osaki
Saburo Minami
author_sort Takashi Wakuda
title Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis model
title_short Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis model
title_full Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis model
title_fullStr Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis model
title_full_unstemmed Protective effects of galacturonic acid-rich vinegar brewed from Japanese pear in a dextran sodium sulfate-induced acute colitis model
title_sort protective effects of galacturonic acid-rich vinegar brewed from japanese pear in a dextran sodium sulfate-induced acute colitis model
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2013-01-01
description The effects of pear vinegar (PV), which was specially brewed for enhanced galacturonic acid content, on the DSS-induced ulcerative colitis (UC) mouse model were evaluated. PV improved clinical symptoms, colon inflammation, and histological tissue injury in the DSS-induced acute UC mouse model. Moreover, PV suppressed inflammation due to acute UC by suppressing the myeloperoxidase (MPO)-mediated activation of inflammatory cells such as leukocytes and decreasing the serum concentration of IL-6. Our results demonstrated the protective action of PV in the DSS-induced acute UC mouse model. On the other hand, commercial apple vinegar did not show a protective effect in the DSS-induced acute UC mouse model. Our findings indicate that PV may act as a new functional food for inflammatory bowel disease patients.
topic Pear vinegar
Inflammatory bowel disease
Functional food
Dextran sodium sulfate
Mice
url http://www.sciencedirect.com/science/article/pii/S1756464612001569
work_keys_str_mv AT takashiwakuda protectiveeffectsofgalacturonicacidrichvinegarbrewedfromjapanesepearinadextransodiumsulfateinducedacutecolitismodel
AT kazuoazuma protectiveeffectsofgalacturonicacidrichvinegarbrewedfromjapanesepearinadextransodiumsulfateinducedacutecolitismodel
AT hiroyukisaimoto protectiveeffectsofgalacturonicacidrichvinegarbrewedfromjapanesepearinadextransodiumsulfateinducedacutecolitismodel
AT shinsukeifuku protectiveeffectsofgalacturonicacidrichvinegarbrewedfromjapanesepearinadextransodiumsulfateinducedacutecolitismodel
AT minorumorimoto protectiveeffectsofgalacturonicacidrichvinegarbrewedfromjapanesepearinadextransodiumsulfateinducedacutecolitismodel
AT ichiroarifuku protectiveeffectsofgalacturonicacidrichvinegarbrewedfromjapanesepearinadextransodiumsulfateinducedacutecolitismodel
AT masahitoasaka protectiveeffectsofgalacturonicacidrichvinegarbrewedfromjapanesepearinadextransodiumsulfateinducedacutecolitismodel
AT takeshitsuka protectiveeffectsofgalacturonicacidrichvinegarbrewedfromjapanesepearinadextransodiumsulfateinducedacutecolitismodel
AT tomohiroimagawa protectiveeffectsofgalacturonicacidrichvinegarbrewedfromjapanesepearinadextransodiumsulfateinducedacutecolitismodel
AT yoshiharuokamoto protectiveeffectsofgalacturonicacidrichvinegarbrewedfromjapanesepearinadextransodiumsulfateinducedacutecolitismodel
AT tomohiroosaki protectiveeffectsofgalacturonicacidrichvinegarbrewedfromjapanesepearinadextransodiumsulfateinducedacutecolitismodel
AT saburominami protectiveeffectsofgalacturonicacidrichvinegarbrewedfromjapanesepearinadextransodiumsulfateinducedacutecolitismodel
_version_ 1721502103278452736

Similar Items