Interplay of Na+ Balance and Immunobiology of Dendritic Cells

Interplay of Na+ Balance and Immunobiology of Dendritic Cells

Local Na+ balance emerges as an important factor of tissue microenvironment. On the one hand, immune cells impact on local Na+ levels. On the other hand, Na+ availability is able to influence immune responses. In contrast to macrophages, our knowledge of dendritic cells (DCs) in this state of affair...

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Main Authors: Patrick Neubert, Agnes Schröder, Dominik N. Müller, Jonathan Jantsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
Na+ balance
antigen-presentation
Nfat5
kidney
skin microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00599/full
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spelling doaj-e4c889f07fd34da19bbbc558d5e6f5ac2020-11-25T02:15:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-03-011010.3389/fimmu.2019.00599433730Interplay of Na+ Balance and Immunobiology of Dendritic CellsPatrick Neubert0Agnes Schröder1Dominik N. Müller2Dominik N. Müller3Jonathan Jantsch4Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg, University of Regensburg, Regensburg, GermanyDepartment of Orthodontics, University Hospital Regensburg, University of Regensburg, Regensburg, GermanyExperimental and Clinical Research Center, A Joint Cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, Berlin, GermanyMax-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, GermanyInstitute of Clinical Microbiology and Hygiene, University Hospital Regensburg, University of Regensburg, Regensburg, GermanyLocal Na+ balance emerges as an important factor of tissue microenvironment. On the one hand, immune cells impact on local Na+ levels. On the other hand, Na+ availability is able to influence immune responses. In contrast to macrophages, our knowledge of dendritic cells (DCs) in this state of affair is rather limited. Current evidence suggests that the impact of increased Na+ on DCs is context dependent. Moreover, it is conceivable that DC immunobiology might also be influenced by Na+-rich-diet-induced changes of the gut microbiome.https://www.frontiersin.org/article/10.3389/fimmu.2019.00599/fulldendritic cellsNa+ balanceantigen-presentationNfat5kidneyskin microenvironment
collection DOAJ
language English
format Article
sources DOAJ
author Patrick Neubert
Agnes Schröder
Dominik N. Müller
Dominik N. Müller
Jonathan Jantsch
spellingShingle Patrick Neubert
Agnes Schröder
Dominik N. Müller
Dominik N. Müller
Jonathan Jantsch
Interplay of Na+ Balance and Immunobiology of Dendritic Cells
Frontiers in Immunology
dendritic cells
Na+ balance
antigen-presentation
Nfat5
kidney
skin microenvironment
author_facet Patrick Neubert
Agnes Schröder
Dominik N. Müller
Dominik N. Müller
Jonathan Jantsch
author_sort Patrick Neubert
title Interplay of Na+ Balance and Immunobiology of Dendritic Cells
title_short Interplay of Na+ Balance and Immunobiology of Dendritic Cells
title_full Interplay of Na+ Balance and Immunobiology of Dendritic Cells
title_fullStr Interplay of Na+ Balance and Immunobiology of Dendritic Cells
title_full_unstemmed Interplay of Na+ Balance and Immunobiology of Dendritic Cells
title_sort interplay of na+ balance and immunobiology of dendritic cells
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2019-03-01
description Local Na+ balance emerges as an important factor of tissue microenvironment. On the one hand, immune cells impact on local Na+ levels. On the other hand, Na+ availability is able to influence immune responses. In contrast to macrophages, our knowledge of dendritic cells (DCs) in this state of affair is rather limited. Current evidence suggests that the impact of increased Na+ on DCs is context dependent. Moreover, it is conceivable that DC immunobiology might also be influenced by Na+-rich-diet-induced changes of the gut microbiome.
topic dendritic cells
Na+ balance
antigen-presentation
Nfat5
kidney
skin microenvironment
url https://www.frontiersin.org/article/10.3389/fimmu.2019.00599/full
work_keys_str_mv AT patrickneubert interplayofnabalanceandimmunobiologyofdendriticcells
AT agnesschroder interplayofnabalanceandimmunobiologyofdendriticcells
AT dominiknmuller interplayofnabalanceandimmunobiologyofdendriticcells
AT dominiknmuller interplayofnabalanceandimmunobiologyofdendriticcells
AT jonathanjantsch interplayofnabalanceandimmunobiologyofdendriticcells
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