Interplay of Na+ Balance and Immunobiology of Dendritic Cells

Interplay of Na+ Balance and Immunobiology of Dendritic Cells

Local Na+ balance emerges as an important factor of tissue microenvironment. On the one hand, immune cells impact on local Na+ levels. On the other hand, Na+ availability is able to influence immune responses. In contrast to macrophages, our knowledge of dendritic cells (DCs) in this state of affair...

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Bibliographic Details
Main Authors: Patrick Neubert, Agnes Schröder, Dominik N. Müller, Jonathan Jantsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
Na+ balance
antigen-presentation
Nfat5
kidney
skin microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00599/full
Description
Summary:Local Na+ balance emerges as an important factor of tissue microenvironment. On the one hand, immune cells impact on local Na+ levels. On the other hand, Na+ availability is able to influence immune responses. In contrast to macrophages, our knowledge of dendritic cells (DCs) in this state of affair is rather limited. Current evidence suggests that the impact of increased Na+ on DCs is context dependent. Moreover, it is conceivable that DC immunobiology might also be influenced by Na+-rich-diet-induced changes of the gut microbiome.
ISSN:1664-3224

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