CRISPR/Cas9 Delivery Mediated with Hydroxyl‐Rich Nanosystems for Gene Editing in Aorta

CRISPR/Cas9 Delivery Mediated with Hydroxyl‐Rich Nanosystems for Gene Editing in Aorta

Abstract A CRISPR/Cas9 system has emerged as a powerful tool for gene editing to treat genetic mutation related diseases. Due to the complete endothelial barrier, effective delivery of the CRISPR/Cas9 system to vasculatures remains a challenge for in vivo gene editing of genetic vascular diseases es...

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Bibliographic Details
Main Authors: Xiaoping Zhang, Chen Xu, Shijuan Gao, Ping Li, Yu Kong, Tiantian Li, Yulin Li, Fu‐Jian Xu, Jie Du
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Advanced Science
Subjects:
aorta disease
cationic carriers
CRISPR‐associated nuclease 9 delivery
genome editing
hydroxyl‐rich
Online Access:https://doi.org/10.1002/advs.201900386

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