Microwave-promoted three-component Hantzsch synthesis of acridinediones under green conditions
In this study, a green and practical approach towards Hantzsch dihydropyridine synthesis of acridine-1,8-diones is introduced. Via the mentioned protocol, the one-pot condensation reaction of structurally diverse aromatic aldehydes, dimedone and NH4OAc was promoted by microwave radiation at solvent...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Growing Science
2019-10-01
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| Series: | Current Chemistry Letters |
| Subjects: | |
| Online Access: | http://www.growingscience.com/ccl/Vol9/ccl_2019_27.pdf |
| Summary: | In this study, a green and practical approach towards Hantzsch dihydropyridine synthesis of acridine-1,8-diones is introduced. Via the mentioned protocol, the one-pot condensation reaction of structurally diverse aromatic aldehydes, dimedone and NH4OAc was promoted by microwave radiation at solvent and catalyst-free conditions. Consequently, acridinedione products were produced in 81‒97% yields within 3‒8 min. The current protocol represents the prominent advantages in terms of the using a simple synthetic procedure, short reaction times, mild reaction conditions, high yield of the products as well as omission of hazardous and cost-effective organic solvents/reagents. |
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| ISSN: | 1927-7296 1927-730X |