Comparative Pharmacokinetics of Hypaconitine after Oral Administration of Pure Hypaconitine, Aconitum carmichaelii Extract and Sini Decoction to Rats

Comparative Pharmacokinetics of Hypaconitine after Oral Administration of Pure Hypaconitine, Aconitum carmichaelii Extract and Sini Decoction to Rats

Hypaconitine (HC) is one of the main aconitum alkaloids in Aconitum carmichaelii (AC), which is considered to be effective on cardiovascular disease, although it also has high toxicity. Sini Decoction (SND), composed of Aconitum carmichaelii, Glycyrrhiza uralensis and Zingiber officinale, is a tradi...

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Bibliographic Details
Main Authors: Wen Zhang, Hai Zhang, Sen Sun, Feng-Feng Sun, Jun Chen, Liang Zhao, Guo-Qing Zhang
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Molecules
Subjects:
hypaconitine
Aconitum carmichaelii
Sini decoction
pharmacokinetics
LC-MS/MS
Online Access:http://www.mdpi.com/1420-3049/20/1/1560

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