Impact of stirring speed, glycerin and sodium chloride concentrations on photoprotective nanoemulsions

• Main Authors: Débora Granemann e Silva, Camila Areias de Oliveira, Daniela DAlmeida Peres, Margarida Pereira, Nicole Pereira, Tânia Santos Almeida, Joana Portugal Mota, Catarina Rosado, Vânia Rodrigues Leite-Silva, Maria Valéria Robles Velasco, André Rolim Baby
• Format: Article
• Language: English
• Published: ALIES - Associação Lusófona para o Desenvolvimento da Investigação e do Ensino das Ciências da Saúde 2014-09-01
• Series: Journal Biomedical and Biopharmaceutical Research (BBR)
• Subjects: Nanoemulsion; Photoprotection; Ethylhexyl methoxycinnamate; Benzophenone-3
• Online Access: http://www.alies.pt/BBR%20Editions/Vol%2011-2-2014/Article9_11n2.pdf

New technologies that improve the physical as the sensory properties of sunscreens can help to increase its continued use and impact on health. The use of nanoemulsions in the development of photoprotective vehicles is an advantage, since nanostructured components may have superior properties regarding their performance when compared to conventional products. The advantages of using nanobiotechnology in manufacture of cosmetic and dermatological formulations arise from the protection of compounds from chemical or enzymatic degradation, from the control of their release, and also to the prolonged retention time of cosmetic ingredients in the stratum corneum. Thus, this study aimed to evaluate the impact of stirring speed and of glycerin and sodium chloride concentrations in the development and effectiveness of a nanoemulsion containing ethylhexyl methoxycinnamate and benzophenone-3. The results of statistical analyses regarding the impact of the variables in the process of nanoemulsion development showed that these parameters affect the phase inversion temperature (PIT). However, this did not affect the particle size and the photoprotective efficacy in vitro.