Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of AML. Here, the authors report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and provide evidence of a direct link between the association of NUP98-PHD finger chimeras with H3K4me3-rich...

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Main Authors:	Yi Zhang, Yiran Guo, Sheryl M. Gough, Jinyong Zhang, Kendra R. Vann, Kuai Li, Ling Cai, Xiaobing Shi, Peter D. Aplan, Gang Greg Wang, Tatiana G. Kutateladze
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17098-4

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spelling	doaj-e4bca98ea1b04bc8b103565804db9ae02021-07-04T11:47:54ZengNature Publishing GroupNature Communications2041-17232020-07-0111111010.1038/s41467-020-17098-4Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusionYi Zhang0Yiran Guo1Sheryl M. Gough2Jinyong Zhang3Kendra R. Vann4Kuai Li5Ling Cai6Xiaobing Shi7Peter D. Aplan8Gang Greg Wang9Tatiana G. Kutateladze10Department of Pharmacology, University of Colorado School of MedicineDepartment of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, The University of North Carolina School of MedicineGenetics Branch, Center for Cancer Research, National Cancer Institute, NIHDepartment of Pharmacology, University of Colorado School of MedicineDepartment of Pharmacology, University of Colorado School of MedicineCenter for Epigenetics, Van Andel Research InstituteDepartment of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, The University of North Carolina School of MedicineCenter for Epigenetics, Van Andel Research InstituteGenetics Branch, Center for Cancer Research, National Cancer Institute, NIHDepartment of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, The University of North Carolina School of MedicineDepartment of Pharmacology, University of Colorado School of MedicineChromosomal NUP98-PHF23 translocation is associated with an aggressive form of AML. Here, the authors report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and provide evidence of a direct link between the association of NUP98-PHD finger chimeras with H3K4me3-rich regions and leukemic transformation.https://doi.org/10.1038/s41467-020-17098-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yi Zhang Yiran Guo Sheryl M. Gough Jinyong Zhang Kendra R. Vann Kuai Li Ling Cai Xiaobing Shi Peter D. Aplan Gang Greg Wang Tatiana G. Kutateladze
spellingShingle	Yi Zhang Yiran Guo Sheryl M. Gough Jinyong Zhang Kendra R. Vann Kuai Li Ling Cai Xiaobing Shi Peter D. Aplan Gang Greg Wang Tatiana G. Kutateladze Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion Nature Communications
author_facet	Yi Zhang Yiran Guo Sheryl M. Gough Jinyong Zhang Kendra R. Vann Kuai Li Ling Cai Xiaobing Shi Peter D. Aplan Gang Greg Wang Tatiana G. Kutateladze
author_sort	Yi Zhang
title	Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
title_short	Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
title_full	Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
title_fullStr	Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
title_full_unstemmed	Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
title_sort	mechanistic insights into chromatin targeting by leukemic nup98-phf23 fusion
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-07-01
description	Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of AML. Here, the authors report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and provide evidence of a direct link between the association of NUP98-PHD finger chimeras with H3K4me3-rich regions and leukemic transformation.
url	https://doi.org/10.1038/s41467-020-17098-4
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Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

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