Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters

Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters

The aim of the study was to investigate the effects of subchronic exposure of zebrafish (Danio rerio) to a fluoroquinolone norfloxacin, using selected oxidative stress parameters as a target. Toxicity tests were performed on zebrafish according to the OECD Guidelines number 203 and number 215. In th...

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Main Authors: Marta Bartoskova, Radka Dobsikova, Vlasta Stancova, Ondrej Pana, Dana Zivna, Lucie Plhalova, Jana Blahova, Petr Marsalek
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/560235
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spelling doaj-e4bba7d5fff645ff9c48e9e21bcc2bbf2020-11-25T01:01:38ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/560235560235Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress ParametersMarta Bartoskova0Radka Dobsikova1Vlasta Stancova2Ondrej Pana3Dana Zivna4Lucie Plhalova5Jana Blahova6Petr Marsalek7Department of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třída 1/3, 61242 Brno, Czech RepublicDepartment of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třída 1/3, 61242 Brno, Czech RepublicDepartment of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třída 1/3, 61242 Brno, Czech RepublicDepartment of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třída 1/3, 61242 Brno, Czech RepublicDepartment of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třída 1/3, 61242 Brno, Czech RepublicDepartment of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třída 1/3, 61242 Brno, Czech RepublicDepartment of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třída 1/3, 61242 Brno, Czech RepublicDepartment of Veterinary Public Health and Animal Welfare, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého třída 1/3, 61242 Brno, Czech RepublicThe aim of the study was to investigate the effects of subchronic exposure of zebrafish (Danio rerio) to a fluoroquinolone norfloxacin, using selected oxidative stress parameters as a target. Toxicity tests were performed on zebrafish according to the OECD Guidelines number 203 and number 215. In the Subchronic Toxicity Test, a significant (P<0.01) increase in the activity of glutathione peroxidase, glutathione S-transferase, and catalase was found. In the test, norfloxacin did not affect lipid peroxidation and catalytic activity of glutathione reductase. From the results, we can conclude that norfloxacin has a negative impact on specific biochemical processes connected with the production of reactive oxygen species in fish tested.http://dx.doi.org/10.1155/2014/560235
collection DOAJ
language English
format Article
sources DOAJ
author Marta Bartoskova
Radka Dobsikova
Vlasta Stancova
Ondrej Pana
Dana Zivna
Lucie Plhalova
Jana Blahova
Petr Marsalek
spellingShingle Marta Bartoskova
Radka Dobsikova
Vlasta Stancova
Ondrej Pana
Dana Zivna
Lucie Plhalova
Jana Blahova
Petr Marsalek
Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters
BioMed Research International
author_facet Marta Bartoskova
Radka Dobsikova
Vlasta Stancova
Ondrej Pana
Dana Zivna
Lucie Plhalova
Jana Blahova
Petr Marsalek
author_sort Marta Bartoskova
title Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters
title_short Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters
title_full Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters
title_fullStr Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters
title_full_unstemmed Norfloxacin—Toxicity for Zebrafish (Danio rerio) Focused on Oxidative Stress Parameters
title_sort norfloxacin—toxicity for zebrafish (danio rerio) focused on oxidative stress parameters
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2014-01-01
description The aim of the study was to investigate the effects of subchronic exposure of zebrafish (Danio rerio) to a fluoroquinolone norfloxacin, using selected oxidative stress parameters as a target. Toxicity tests were performed on zebrafish according to the OECD Guidelines number 203 and number 215. In the Subchronic Toxicity Test, a significant (P<0.01) increase in the activity of glutathione peroxidase, glutathione S-transferase, and catalase was found. In the test, norfloxacin did not affect lipid peroxidation and catalytic activity of glutathione reductase. From the results, we can conclude that norfloxacin has a negative impact on specific biochemical processes connected with the production of reactive oxygen species in fish tested.
url http://dx.doi.org/10.1155/2014/560235
work_keys_str_mv AT martabartoskova norfloxacintoxicityforzebrafishdanioreriofocusedonoxidativestressparameters
AT radkadobsikova norfloxacintoxicityforzebrafishdanioreriofocusedonoxidativestressparameters
AT vlastastancova norfloxacintoxicityforzebrafishdanioreriofocusedonoxidativestressparameters
AT ondrejpana norfloxacintoxicityforzebrafishdanioreriofocusedonoxidativestressparameters
AT danazivna norfloxacintoxicityforzebrafishdanioreriofocusedonoxidativestressparameters
AT lucieplhalova norfloxacintoxicityforzebrafishdanioreriofocusedonoxidativestressparameters
AT janablahova norfloxacintoxicityforzebrafishdanioreriofocusedonoxidativestressparameters
AT petrmarsalek norfloxacintoxicityforzebrafishdanioreriofocusedonoxidativestressparameters
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