In Silico Discovery of a Substituted 6-Methoxy-quinalidine with Leishmanicidal Activity in Leishmania infantum

In Silico Discovery of a Substituted 6-Methoxy-quinalidine with Leishmanicidal Activity in Leishmania infantum

There is an urgent need for the discovery of new antileishmanial drugs with a new mechanism of action. Type 2 NADH dehydrogenase from Leishmania infantum (LiNDH2) is an enzyme of the parasite’s respiratory system, which catalyzes the electron transfer from NADH to ubiquinone without coupled proton p...

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Bibliographic Details
Main Authors: Strahinja Stevanović, Andrej Perdih, Milan Senćanski, Sanja Glišić, Margarida Duarte, Ana M. Tomás, Filipa V. Sena, Filipe M. Sousa, Manuela M. Pereira, Tom Solmajer
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
Leishmania infantum alternative NADH dehydrogenase (LiNDH2)
antileishmanial drugs
Leishmania infantum virtual screening
drug design
Online Access:http://www.mdpi.com/1420-3049/23/4/772

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