The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

Abstract Cytokines such as IL-6, TNF-α and IL-1β trigger inflammatory cascades which may play a role in the pathogenesis of chronic kidney disease (CKD)-associated cachexia. CKD was induced by 5/6 nephrectomy in mice. We studied energy homeostasis in Il1β −/− /CKD, Il6 −/− /CKD and Tnfα −/− /CKD mic...

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Bibliographic Details
Main Authors: Wai W. Cheung, Ronghao Zheng, Sheng Hao, Zhen Wang, Alex Gonzalez, Ping Zhou, Hal M. Hoffman, Robert H. Mak
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94565-y

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