Theoretical Studies Aimed at Finding FLT3 Inhibitors and a Promising Compound and Molecular Pattern with Dual Aurora B/FLT3 Activity

Theoretical Studies Aimed at Finding FLT3 Inhibitors and a Promising Compound and Molecular Pattern with Dual Aurora B/FLT3 Activity

FLT3 and dual Aurora B/FLT3 inhibitors have shown relevance in the search for promising new anticancer compounds, mainly for acute myeloid leukemia (AML). This study was designed to investigate the interactions between human FLT3 in the kinase domain with several indolin−2-one derivatives, structura...

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Bibliographic Details
Main Authors: Ítalo Antônio Fernandes, Déborah Braga Resende, Teodorico Castro Ramalho, Kamil Kuca, Elaine Fontes Ferreira da Cunha
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
indolin−2-one derivatives
dual Aurora B/FLT3 inhibitors
computational chemistry
Online Access:https://www.mdpi.com/1420-3049/25/7/1726

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