Monoclonal Antibody Aggregation Associated with Free Radical Induced Oxidation

Monoclonal Antibody Aggregation Associated with Free Radical Induced Oxidation

Oxidation is an important degradation pathway of protein drugs. The susceptibility to oxidation is a common concern for therapeutic proteins as it may impact product efficacy and patient safety. In this work, we used 2,2′-azobis (2-amidinopropane) dihydrochloride (AAPH) as an oxidative stress reagen...

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Bibliographic Details
Main Authors: Kai Zheng, Diya Ren, Y. John Wang, Wayne Lilyestrom, Thomas Scherer, Justin K. Y. Hong, Junyan A. Ji
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
monoclonal antibody
free radical
protein aggregation
oxidation
excipient
Online Access:https://www.mdpi.com/1422-0067/22/8/3952

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