Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

Natural killer (NK) cells are important for eliminating cells under stress or infected by virus, and may have a function in anti-HIV immunity. Here the authors show that different NK-activating stimuli induce distinct transcriptional fingerprints in human NK cells that are analogous to changes cause...

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Main Authors:	Margaret C. Costanzo, Dohoon Kim, Matthew Creegan, Kerri G. Lal, Julie A. Ake, Jeffrey R. Currier, Hendrik Streeck, Merlin L. Robb, Nelson L. Michael, Diane L. Bolton, Nicholas J. Steers, Michael A. Eller
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03618-w

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spelling	doaj-e4a9908351094565842dd84f98c3598c2021-05-11T09:30:37ZengNature Publishing GroupNature Communications2041-17232018-03-019111610.1038/s41467-018-03618-wTranscriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccinationMargaret C. Costanzo0Dohoon Kim1Matthew Creegan2Kerri G. Lal3Julie A. Ake4Jeffrey R. Currier5Hendrik Streeck6Merlin L. Robb7Nelson L. Michael8Diane L. Bolton9Nicholas J. Steers10Michael A. Eller11U.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchVirus Diseases Branch, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchDivision of Nephrology, Columbia University Medical CenterU.S. Military HIV Research Program, Walter Reed Army Institute of ResearchNatural killer (NK) cells are important for eliminating cells under stress or infected by virus, and may have a function in anti-HIV immunity. Here the authors show that different NK-activating stimuli induce distinct transcriptional fingerprints in human NK cells that are analogous to changes caused by HIV vaccination or chronic infection.https://doi.org/10.1038/s41467-018-03618-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Margaret C. Costanzo Dohoon Kim Matthew Creegan Kerri G. Lal Julie A. Ake Jeffrey R. Currier Hendrik Streeck Merlin L. Robb Nelson L. Michael Diane L. Bolton Nicholas J. Steers Michael A. Eller
spellingShingle	Margaret C. Costanzo Dohoon Kim Matthew Creegan Kerri G. Lal Julie A. Ake Jeffrey R. Currier Hendrik Streeck Merlin L. Robb Nelson L. Michael Diane L. Bolton Nicholas J. Steers Michael A. Eller Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination Nature Communications
author_facet	Margaret C. Costanzo Dohoon Kim Matthew Creegan Kerri G. Lal Julie A. Ake Jeffrey R. Currier Hendrik Streeck Merlin L. Robb Nelson L. Michael Diane L. Bolton Nicholas J. Steers Michael A. Eller
author_sort	Margaret C. Costanzo
title	Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination
title_short	Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination
title_full	Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination
title_fullStr	Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination
title_full_unstemmed	Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination
title_sort	transcriptomic signatures of nk cells suggest impaired responsiveness in hiv-1 infection and increased activity post-vaccination
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-03-01
description	Natural killer (NK) cells are important for eliminating cells under stress or infected by virus, and may have a function in anti-HIV immunity. Here the authors show that different NK-activating stimuli induce distinct transcriptional fingerprints in human NK cells that are analogous to changes caused by HIV vaccination or chronic infection.
url	https://doi.org/10.1038/s41467-018-03618-w
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Transcriptomic signatures of NK cells suggest impaired responsiveness in HIV-1 infection and increased activity post-vaccination

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