Calcium Oscillations in Pancreatic α-cells Rely on Noise and ATP-Driven Changes in Membrane Electrical Activity

Calcium Oscillations in Pancreatic α-cells Rely on Noise and ATP-Driven Changes in Membrane Electrical Activity

In pancreatic α-cells, intracellular Ca2+ ([Ca2+]i) acts as a trigger for secretion of glucagon, a hormone that plays a key role in blood glucose homeostasis. Intracellular Ca2+ dynamics in these cells are governed by the electrical activity of voltage-gated ion channels, among which ATP-sensitive K...

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Bibliographic Details
Main Authors: Virginia González-Vélez, Anthony Piron, Geneviève Dupont
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Physiology
Subjects:
computational model
ATP-sensitive potassium channels
action potential
Langevin equation
stochastic channel
plasma-membrane Ca2+ ATPase
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.602844/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.602844/full

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