Novel 2-mercapto imidazole and triazole derivatives as potent TGR5 receptor agonists

TGR5 is a bile acid G protein-coupled receptor (GPCR), which is an attractive therapeutic target for the treatment of obesity, and its highly associated Type 2 diabetes. Activation of TGR5 promotes secretion of glucagon like peptide-1 (GLP-1) and activates insulin secretion. Series of novel 2-mercap...

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Bibliographic Details
Main Authors: Sameer Agarwal, Santosh Sasane, Jeevan Kumar, Brijesh Darji, Hitesh Bhayani, Shubhangi Soman, Neelima Kulkarni, Mukul Jain
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Medicine in Drug Discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2590098619300028

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