Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices.

Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices.

Intravascular devices for continuous glucose monitoring are promising tools for the follow up and treatment of diabetic patients. Limiting the inflammatory response to the implanted devices in order to achieve better biocompatibility is a critical challenge. Herein we report on the production and th...

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Main Authors: Guillaume Le Saux, Laurent Plawinski, Sylvain Nlate, Jean Ripoche, Thierry Buffeteau, Marie-Christine Durrieu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4777356?pdf=render
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spelling doaj-e47a672d905247e48d9b111729c8f2e62020-11-25T02:32:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e015070610.1371/journal.pone.0150706Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices.Guillaume Le SauxLaurent PlawinskiSylvain NlateJean RipocheThierry BuffeteauMarie-Christine DurrieuIntravascular devices for continuous glucose monitoring are promising tools for the follow up and treatment of diabetic patients. Limiting the inflammatory response to the implanted devices in order to achieve better biocompatibility is a critical challenge. Herein we report on the production and the characterization of gold surfaces covalently derivatized with the peptide α-alpha-melanocyte stimulating hormone (α-MSH), with a quantifiable surface density. In vitro study demonstrated that the tethered α-MSH is able to decrease the expression of an inflammatory cytokine produced by endothelial cells.http://europepmc.org/articles/PMC4777356?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Guillaume Le Saux
Laurent Plawinski
Sylvain Nlate
Jean Ripoche
Thierry Buffeteau
Marie-Christine Durrieu
spellingShingle Guillaume Le Saux
Laurent Plawinski
Sylvain Nlate
Jean Ripoche
Thierry Buffeteau
Marie-Christine Durrieu
Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices.
PLoS ONE
author_facet Guillaume Le Saux
Laurent Plawinski
Sylvain Nlate
Jean Ripoche
Thierry Buffeteau
Marie-Christine Durrieu
author_sort Guillaume Le Saux
title Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices.
title_short Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices.
title_full Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices.
title_fullStr Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices.
title_full_unstemmed Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices.
title_sort beneficial effect of covalently grafted α-msh on endothelial release of inflammatory mediators for applications in implantable devices.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2016-01-01
description Intravascular devices for continuous glucose monitoring are promising tools for the follow up and treatment of diabetic patients. Limiting the inflammatory response to the implanted devices in order to achieve better biocompatibility is a critical challenge. Herein we report on the production and the characterization of gold surfaces covalently derivatized with the peptide α-alpha-melanocyte stimulating hormone (α-MSH), with a quantifiable surface density. In vitro study demonstrated that the tethered α-MSH is able to decrease the expression of an inflammatory cytokine produced by endothelial cells.
url http://europepmc.org/articles/PMC4777356?pdf=render
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