Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease

Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease

Abstract Given the chronic inflammatory nature of Parkinson’s disease (PD), T cell immunity may be important for disease onset. Here, we performed single-cell transcriptome and TCR sequencing, and conducted integrative analyses to decode composition, function and lineage relationship of T cells in t...

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Bibliographic Details
Main Authors: Pingping Wang, Lifen Yao, Meng Luo, Wenyang Zhou, Xiyun Jin, Zhaochun Xu, Shi Yan, Yiqun Li, Chang Xu, Rui Cheng, Yan Huang, Xiaoyu Lin, Kexin Ma, Huimin Cao, Hongxin Liu, Guangfu Xue, Fang Han, Huan Nie, Qinghua Jiang
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-021-00280-3

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