The efficacy and safety of anlotinib treatment for advanced lung cancer

• Main Authors: Shao L, Wang W, Song Z, Zhang Y
• Format: Article
• Language: English
• Published: Dove Medical Press 2019-08-01
• Series: OncoTargets and Therapy
• Subjects: lung cancer; anlotinib; VEGF; efficacy; safety
• Online Access: https://www.dovepress.com/the-efficacy-and-safety-of-anlotinib-treatment-for-advanced-lung-cance-peer-reviewed-article-OTT

Lan Shao,1,2 Wenxian Wang,1 Zhengbo Song,1,2 Yiping Zhang1,21Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People’s Republic of China; 2Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People’s Republic of ChinaObjective: Anlotinib is an oral novel multi-target tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor, fibroblast growth factor receptor, platelet-derived growth factor receptor, and stem cell factor receptor (c-Kit). The aim of this study was to evaluate the efficacy and safety of anlotinib treatment in advanced lung cancer in the real world.Methods: We evaluated the efficacy and toxicity of apatinib in patients with previously treated advanced lung cancer from 2018 to 2019 in Zhejiang Cancer Hospital. Survival analysis was performed by the Kaplan–Meier method.Results: Fifty-eight patients were included in the present study. Thirty-one of these patients received anlotinib treatment as a third line and 27 patients received further therapy.  All 58 patients had therapeutic evaluation and 46 patients acquired progression-free survival evaluation. Ten patients achieved partial response (PR), and 36 achieved stable disease (SD), representing a response rate of 17.2% and a disease control rate of 77.6%. Median progression-free survival was 3.3 months (95% CI 1.595–5.071). The toxicities associated with anlotinib were generally acceptable with a total grade 3/4 toxicity of 5.2%. The toxicities of anlotinib were generally tolerated and the common toxicities were hand–foot syndrome and hypertension.Conclusion: In the third-line or more-line treatment of advanced lung cancer, anlotinib appears to have some activity when utilized as a salvage treatment. Adverse reactions are controllable.Keywords: lung cancer, anlotinib, VEGF, efficacy, safety