Unveiling a CD70-positive subset of cancer-associated fibroblasts marked by pro-migratory activity and thriving regulatory T cell accumulation

Unveiling a CD70-positive subset of cancer-associated fibroblasts marked by pro-migratory activity and thriving regulatory T cell accumulation

Cancer-associated fibroblasts (CAFs) are involved in the proliferative and invasive behavior of colorectal cancer (CRC). Nonetheless, CAFs represent a heterogeneous population with both cancer-promoting and cancer-restraining actions, lacking specific markers to target them. Expression of the immune...

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Bibliographic Details
Main Authors: Julie Jacobs, Vanessa Deschoolmeester, Karen Zwaenepoel, Tal Flieswasser, Christophe Deben, Jolien Van den Bossche, Christophe Hermans, Christian Rolfo, Marc Peeters, Olivier De Wever, Filip Lardon, Vasiliki Siozopoulou, Evelien Smits, Patrick Pauwels
Format: Article
Language:English
Published: Taylor & Francis Group 2018-07-01
Series:OncoImmunology
Subjects:
cancer-associated fibroblasts
cd70
regulatory t cells
colorectal cancer
biomarker
migration
prognosis
immunotherapy
tumor microenvironment
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1440167

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