Creating a novel origin of replication through modulating DNA-protein interfaces.

While the molecular mechanisms of DNA-protein specificity at the origin of replication have been determined in many model organisms, these interactions remain unknown in the majority of higher eukaryotes and numerous vertebrate viruses. Similar to many viral origins of replication, adeno-associated...

Full description

Bibliographic Details
Main Authors: F Curtis Hewitt, R Jude Samulski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2809752?pdf=render