An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

Melanoma persister cells are tolerant to anti-BRAF and anti-MEK inhibition and can trigger cancer relapse. Here the authors show that a subset of N6-methyladenosine modified mRNAs is translationally activated in persister cells. This preferential translation can be abrogated via eIF4A inhibition.

Bibliographic Details
Main Authors:	Shensi Shen, Sara Faouzi, Amandine Bastide, Sylvain Martineau, Hélène Malka-Mahieu, Yu Fu, Xiaoxiao Sun, Christine Mateus, Emilie Routier, Severine Roy, Laurent Desaubry, Fabrice André, Alexander Eggermont, Alexandre David, Jean-Yves Scoazec, Stéphan Vagner, Caroline Robert
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13360-6

id	doaj-e47491eb7c3744b2a9a1e54104826b8f
record_format	Article
spelling	doaj-e47491eb7c3744b2a9a1e54104826b8f2021-05-11T11:28:42ZengNature Publishing GroupNature Communications2041-17232019-12-0110111410.1038/s41467-019-13360-6An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cellsShensi Shen0Sara Faouzi1Amandine Bastide2Sylvain Martineau3Hélène Malka-Mahieu4Yu Fu5Xiaoxiao Sun6Christine Mateus7Emilie Routier8Severine Roy9Laurent Desaubry10Fabrice André11Alexander Eggermont12Alexandre David13Jean-Yves Scoazec14Stéphan Vagner15Caroline Robert16INSERM U981, Gustave Roussy Cancer CampusINSERM U981, Gustave Roussy Cancer CampusIGF, CNRS, INSERM, University MontpellierInstitut Curie, PSL Research University, CNRS UMR3348Institut Curie, PSL Research University, CNRS UMR3348INSERM U981, Gustave Roussy Cancer CampusDepartment of Pharmaceutical Chemistry, University of CaliforniaDermato-Oncology, Gustave Roussy Cancer CampusDermato-Oncology, Gustave Roussy Cancer CampusDermato-Oncology, Gustave Roussy Cancer CampusCNRS-Strasbourg UniversityINSERM U981, Gustave Roussy Cancer CampusUniversité Paris-Sud, Université Paris-SaclayIGF, CNRS, INSERM, University MontpellierUniversité Paris-Sud, Université Paris-SaclayInstitut Curie, PSL Research University, CNRS UMR3348INSERM U981, Gustave Roussy Cancer CampusMelanoma persister cells are tolerant to anti-BRAF and anti-MEK inhibition and can trigger cancer relapse. Here the authors show that a subset of N6-methyladenosine modified mRNAs is translationally activated in persister cells. This preferential translation can be abrogated via eIF4A inhibition.https://doi.org/10.1038/s41467-019-13360-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shensi Shen Sara Faouzi Amandine Bastide Sylvain Martineau Hélène Malka-Mahieu Yu Fu Xiaoxiao Sun Christine Mateus Emilie Routier Severine Roy Laurent Desaubry Fabrice André Alexander Eggermont Alexandre David Jean-Yves Scoazec Stéphan Vagner Caroline Robert
spellingShingle	Shensi Shen Sara Faouzi Amandine Bastide Sylvain Martineau Hélène Malka-Mahieu Yu Fu Xiaoxiao Sun Christine Mateus Emilie Routier Severine Roy Laurent Desaubry Fabrice André Alexander Eggermont Alexandre David Jean-Yves Scoazec Stéphan Vagner Caroline Robert An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells Nature Communications
author_facet	Shensi Shen Sara Faouzi Amandine Bastide Sylvain Martineau Hélène Malka-Mahieu Yu Fu Xiaoxiao Sun Christine Mateus Emilie Routier Severine Roy Laurent Desaubry Fabrice André Alexander Eggermont Alexandre David Jean-Yves Scoazec Stéphan Vagner Caroline Robert
author_sort	Shensi Shen
title	An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
title_short	An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
title_full	An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
title_fullStr	An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
title_full_unstemmed	An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells
title_sort	epitranscriptomic mechanism underlies selective mrna translation remodelling in melanoma persister cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-12-01
description	Melanoma persister cells are tolerant to anti-BRAF and anti-MEK inhibition and can trigger cancer relapse. Here the authors show that a subset of N6-methyladenosine modified mRNAs is translationally activated in persister cells. This preferential translation can be abrogated via eIF4A inhibition.
url	https://doi.org/10.1038/s41467-019-13360-6
work_keys_str_mv	AT shensishen anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT sarafaouzi anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT amandinebastide anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT sylvainmartineau anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT helenemalkamahieu anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT yufu anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT xiaoxiaosun anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT christinemateus anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT emilieroutier anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT severineroy anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT laurentdesaubry anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT fabriceandre anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT alexandereggermont anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT alexandredavid anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT jeanyvesscoazec anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT stephanvagner anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT carolinerobert anepitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT shensishen epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT sarafaouzi epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT amandinebastide epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT sylvainmartineau epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT helenemalkamahieu epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT yufu epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT xiaoxiaosun epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT christinemateus epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT emilieroutier epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT severineroy epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT laurentdesaubry epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT fabriceandre epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT alexandereggermont epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT alexandredavid epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT jeanyvesscoazec epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT stephanvagner epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells AT carolinerobert epitranscriptomicmechanismunderliesselectivemrnatranslationremodellinginmelanomapersistercells
_version_	1721446585548668928

An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells

Similar Items