Involvement of Phosphatase and Tensin Homolog in Cyclin-Dependent Kinase 4/6 Inhibitor-Induced Blockade of Glioblastoma

Involvement of Phosphatase and Tensin Homolog in Cyclin-Dependent Kinase 4/6 Inhibitor-Induced Blockade of Glioblastoma

Dysregulation of retinoblastoma (Rb) signaling pathway have been established as a requirement for glioblastoma (GBM) initiation and progression, which suggests that blockade of CDK4/6-Rb signaling axis for GBM treatment. Palbociclib, a selective inhibitor of the cyclin-dependent kinases CDK4/6, has...

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Bibliographic Details
Main Authors: Songlin Liu, Dun Yuan, Yifeng Li, Qi Qi, Bingzhong Guo, Shun Yang, Jilin Zhou, Lu Xu, Tiange Chen, Chenxing Yang, Junyu Liu, Buyan Li, Li Yao, Weixi Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
glioblastoma
PTEN
CDK4/6 inhibitor
palbociclib
sensitivity
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01316/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01316/full

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