The Histone Methyltransferase SETDB1 Modulates Survival of Spermatogonial Stem/Progenitor Cells Through NADPH Oxidase

The Histone Methyltransferase SETDB1 Modulates Survival of Spermatogonial Stem/Progenitor Cells Through NADPH Oxidase

SETDB1, a histone H3 lysine 9 (H3K9) methyltransferase, is crucial in meiosis and embryo development. This study aimed to investigate whether SETDB1 was associated with spermatogonial stem cells (SSC) homeostasis. We found that knockdown of Setdb1 impaired cell proliferation, led to an increase in r...

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Bibliographic Details
Main Authors: Xueliang Li, Xiaoxu Chen, Yingdong Liu, Pengfei Zhang, Yi Zheng, Wenxian Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Genetics
Subjects:
SETDB1
H3K9me3
NOX4
ROS
spermatogonial stem cell
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00997/full

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