Granular IgM deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis

Granular IgM deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis

Diffuse Cutaneous mastocytosis (DCM) occurs due to abnormal accumulation of mast cells in the skin. We report an 8-month-old infant presented papulovesicular lesions, predominantly on the trunk. Skin biopsy revealed subepidermal bulla, interspersed with mast cells, eosinophils and neutrophils. Direc...

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Main Authors: Subramanian Kumudhini, Raghavendra Rao, Gauri Salgaonkar, Sricharith Shetty, Sathish Pai
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Indian Journal of Dermatology
Subjects:
Diffuse cutaneous mastocytosis
granular IgM deposition
vesiculobullous lesions
Online Access:http://www.e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=5;spage=581;epage=581;aulast=Kumudhini
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spelling doaj-e4506c132dcb41d9b3933446010feb032020-11-25T02:47:15ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112016-01-0161558158110.4103/0019-5154.190134Granular IgM deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosisSubramanian KumudhiniRaghavendra RaoGauri SalgaonkarSricharith ShettySathish PaiDiffuse Cutaneous mastocytosis (DCM) occurs due to abnormal accumulation of mast cells in the skin. We report an 8-month-old infant presented papulovesicular lesions, predominantly on the trunk. Skin biopsy revealed subepidermal bulla, interspersed with mast cells, eosinophils and neutrophils. Direct immunofluorescence microscopy of perilesional skin revealed nonspecific deposition of IgM in granular pattern along the dermoepidermal junction.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=5;spage=581;epage=581;aulast=KumudhiniDiffuse cutaneous mastocytosisgranular IgM depositionvesiculobullous lesions
collection DOAJ
language English
format Article
sources DOAJ
author Subramanian Kumudhini
Raghavendra Rao
Gauri Salgaonkar
Sricharith Shetty
Sathish Pai
spellingShingle Subramanian Kumudhini
Raghavendra Rao
Gauri Salgaonkar
Sricharith Shetty
Sathish Pai
Granular IgM deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis
Indian Journal of Dermatology
Diffuse cutaneous mastocytosis
granular IgM deposition
vesiculobullous lesions
author_facet Subramanian Kumudhini
Raghavendra Rao
Gauri Salgaonkar
Sricharith Shetty
Sathish Pai
author_sort Subramanian Kumudhini
title Granular IgM deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis
title_short Granular IgM deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis
title_full Granular IgM deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis
title_fullStr Granular IgM deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis
title_full_unstemmed Granular IgM deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis
title_sort granular igm deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis
publisher Wolters Kluwer Medknow Publications
series Indian Journal of Dermatology
issn 0019-5154
1998-3611
publishDate 2016-01-01
description Diffuse Cutaneous mastocytosis (DCM) occurs due to abnormal accumulation of mast cells in the skin. We report an 8-month-old infant presented papulovesicular lesions, predominantly on the trunk. Skin biopsy revealed subepidermal bulla, interspersed with mast cells, eosinophils and neutrophils. Direct immunofluorescence microscopy of perilesional skin revealed nonspecific deposition of IgM in granular pattern along the dermoepidermal junction.
topic Diffuse cutaneous mastocytosis
granular IgM deposition
vesiculobullous lesions
url http://www.e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=5;spage=581;epage=581;aulast=Kumudhini
work_keys_str_mv AT subramaniankumudhini granularigmdepositionatbasementmembranezoneinaninfantwithdiffusecutaneousmastocytosis
AT raghavendrarao granularigmdepositionatbasementmembranezoneinaninfantwithdiffusecutaneousmastocytosis
AT gaurisalgaonkar granularigmdepositionatbasementmembranezoneinaninfantwithdiffusecutaneousmastocytosis
AT sricharithshetty granularigmdepositionatbasementmembranezoneinaninfantwithdiffusecutaneousmastocytosis
AT sathishpai granularigmdepositionatbasementmembranezoneinaninfantwithdiffusecutaneousmastocytosis
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