Granular IgM deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis

Granular IgM deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis

Diffuse Cutaneous mastocytosis (DCM) occurs due to abnormal accumulation of mast cells in the skin. We report an 8-month-old infant presented papulovesicular lesions, predominantly on the trunk. Skin biopsy revealed subepidermal bulla, interspersed with mast cells, eosinophils and neutrophils. Direc...

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Bibliographic Details
Main Authors: Subramanian Kumudhini, Raghavendra Rao, Gauri Salgaonkar, Sricharith Shetty, Sathish Pai
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Indian Journal of Dermatology
Subjects:
Diffuse cutaneous mastocytosis
granular IgM deposition
vesiculobullous lesions
Online Access:http://www.e-ijd.org/article.asp?issn=0019-5154;year=2016;volume=61;issue=5;spage=581;epage=581;aulast=Kumudhini
Description
Summary:Diffuse Cutaneous mastocytosis (DCM) occurs due to abnormal accumulation of mast cells in the skin. We report an 8-month-old infant presented papulovesicular lesions, predominantly on the trunk. Skin biopsy revealed subepidermal bulla, interspersed with mast cells, eosinophils and neutrophils. Direct immunofluorescence microscopy of perilesional skin revealed nonspecific deposition of IgM in granular pattern along the dermoepidermal junction.
ISSN:0019-5154
1998-3611

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