Effects of Different Ligands in the Notch Signaling Pathway on the Proliferation and Transdifferentiation of Primary Type II Alveolar Epithelial Cells

Effects of Different Ligands in the Notch Signaling Pathway on the Proliferation and Transdifferentiation of Primary Type II Alveolar Epithelial Cells

Background: Transdifferentiation of type II alveolar epithelial cells (AECII) into type I alveolar epithelial cells (AECI) is involved in neonatal respiratory distress syndrome (NRDS). Different ligands of the Notch pathway could have different effects on AECII transdifferentiation.Objective: To inv...

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Bibliographic Details
Main Authors: Xiuxiang Liu, Xiaoxi Zhu, Guoqing Zhu, Chaoyun Wang, Ruiwei Gao, Jinshuai Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pediatrics
Subjects:
alveolar type II epithelial cells
Notch
Dlk1
Jagged1
respiratory distress syndrome of newborn
Online Access:https://www.frontiersin.org/article/10.3389/fped.2020.00452/full

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