GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact

GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact

GPR139, a Gq-coupled receptor that is activated by the essential amino acids L-tryptophan and L-phenylalanine, is predominantly expressed in the brain and pituitary. The physiological function of GPR139 remains elusive despite the availability of pharmacological tool agonist compounds and knock-out...

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Bibliographic Details
Main Authors: Lien Wang, Grace Lee, Chester Kuei, Xiang Yao, Anthony Harrington, Pascal Bonaventure, Timothy W. Lovenberg, Changlu Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Neuroscience
Subjects:
GPR139
dopamine D2 receptor
co-expression
in situ hybridization
in vitro interaction
calcium mobilization
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00281/full

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