Regulation of Geldanamycin Biosynthesis by Cluster-Situated Transcription Factors and the Master Regulator PhoP

Regulation of Geldanamycin Biosynthesis by Cluster-Situated Transcription Factors and the Master Regulator PhoP

Geldanamycin and the closely related herbimycins A, B, and C are benzoquinone-type ansamycins with antitumoral activity. They are produced by <i>Streptomyces hygroscopicus</i> var. <i>geldanus</i>, <i>Streptomyces lydicus</i> and <i>Streptomyces autolyticus&...

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Bibliographic Details
Main Authors: Juan F. Martín, Angelina Ramos, Paloma Liras
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Antibiotics
Subjects:
geldanamycins
<i>Streptomyces hygroscopicus</i>
antitumorals
biosynthesis
gene cluster
phosphate control
Online Access:https://www.mdpi.com/2079-6382/8/3/87

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