Sonic Hedgehog Signaling Regulates Hematopoietic Stem/Progenitor Cell Activation during the Granulopoietic Response to Systemic Bacterial Infection

Sonic Hedgehog Signaling Regulates Hematopoietic Stem/Progenitor Cell Activation during the Granulopoietic Response to Systemic Bacterial Infection

Activation and reprogramming of hematopoietic stem/progenitor cells play a critical role in the granulopoietic response to bacterial infection. Our current study determined the significance of Sonic hedgehog (SHH) signaling in the regulation of hematopoietic precursor cell activity during the host d...

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Bibliographic Details
Main Authors:	Xin Shi, Shengcai Wei, Kevin J. Simms, Devan N. Cumpston, Thomas J. Ewing, Ping Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-02-01
Series:	Frontiers in Immunology
Subjects:	hedgehog signaling hematopoietic stem cells progenitor cells the granulopoietic response bacterial infection
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00349/full

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