Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus

Diabetic peripheral neuropathy (DPN) involves sensory and motor nerves, resulting in demyelination as well as axonal degeneration. This study was conducted to describe the pattern of lower limb nerve involvement in children with type 1 diabetes mellitus (DM) based on the parameters of nerve conducti...

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Main Authors: Nimat Abuelwafaa, Hana Ahmed, Ilham Omer, Mohamed Abdullah, Ammar Ahmed, Afraa Musa
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2019/2435261
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spelling doaj-e43fee59b73c40038b57e3a7b6d9ed142020-11-25T00:29:19ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532019-01-01201910.1155/2019/24352612435261Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes MellitusNimat Abuelwafaa0Hana Ahmed1Ilham Omer2Mohamed Abdullah3Ammar Ahmed4Afraa Musa5Department of Physiology, Faculty of Medicine, University of Khartoum, 11111, SudanDepartment of Physiology, Faculty of Medicine, University of Khartoum, 11111, SudanDepartment of Paediatrics and Child Health, Faculty of Medicine, University of Khartoum, 11111, SudanDepartment of Paediatrics and Child Health, Faculty of Medicine, University of Khartoum, 11111, SudanDepartment of Physiology, Faculty of Medicine, University of Khartoum, 11111, SudanDepartment of Physiology, Faculty of Medicine, University of Khartoum, 11111, SudanDiabetic peripheral neuropathy (DPN) involves sensory and motor nerves, resulting in demyelination as well as axonal degeneration. This study was conducted to describe the pattern of lower limb nerve involvement in children with type 1 diabetes mellitus (DM) based on the parameters of nerve conduction study (NCS). This cross-sectional study recruited 50 children with type 1 DM having mean disease duration of 4.92±3.84 years who attended the referred clinic in Sudan Childhood Diabetes Center. Their mean age was 15.00±2.19 years, 42% were males, and 58% were females. Twenty six matched healthy control subjects were involved; their mean age was 13.88±2.46 years, 38.46% were males, and 61.54% were females. Bilateral NCS of the sensory and motor lower limb nerves was performed using Medelec Synergy machine. Interpretation of the patients’ results was based on our own control reference values. Data was analysed using IBM SPSS statistics. Out of the 50 diabetic patients, 44 (88%) had electrophysiological evidence of peripheral neuropathy (abnormalities in at least two of the electrophysiological parameters). The majority (68.2%) had motor involvement and 31.8% had sensorimotor, while none of them (0%) had pure sensory involvement. Regarding abnormal NCS parameters (conduction velocity vs. amplitude of the compound action potential), conduction slowing feature predominated in 61.4% and only few (6.8%) showed amplitude reduction, while 31.8% showed mixed features. The most frequently affected nerve was the common peroneal, followed by posterior tibial, and the least was the sural nerve. The most sensitive parameter was the common peroneal conduction velocity. Motor precedes sensory nerve involvement. The most frequent neurophysiological abnormality was the conduction slowing, and the common peroneal was the most vulnerable nerve. These findings signify generation of a protocol for early screening of neuropathy in children with type 1 diabetes.http://dx.doi.org/10.1155/2019/2435261
collection DOAJ
language English
format Article
sources DOAJ
author Nimat Abuelwafaa
Hana Ahmed
Ilham Omer
Mohamed Abdullah
Ammar Ahmed
Afraa Musa
spellingShingle Nimat Abuelwafaa
Hana Ahmed
Ilham Omer
Mohamed Abdullah
Ammar Ahmed
Afraa Musa
Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus
Journal of Diabetes Research
author_facet Nimat Abuelwafaa
Hana Ahmed
Ilham Omer
Mohamed Abdullah
Ammar Ahmed
Afraa Musa
author_sort Nimat Abuelwafaa
title Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus
title_short Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus
title_full Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus
title_fullStr Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus
title_full_unstemmed Electrophysiological Characterization of Neuropathy Complicating Type 1 Diabetes Mellitus
title_sort electrophysiological characterization of neuropathy complicating type 1 diabetes mellitus
publisher Hindawi Limited
series Journal of Diabetes Research
issn 2314-6745
2314-6753
publishDate 2019-01-01
description Diabetic peripheral neuropathy (DPN) involves sensory and motor nerves, resulting in demyelination as well as axonal degeneration. This study was conducted to describe the pattern of lower limb nerve involvement in children with type 1 diabetes mellitus (DM) based on the parameters of nerve conduction study (NCS). This cross-sectional study recruited 50 children with type 1 DM having mean disease duration of 4.92±3.84 years who attended the referred clinic in Sudan Childhood Diabetes Center. Their mean age was 15.00±2.19 years, 42% were males, and 58% were females. Twenty six matched healthy control subjects were involved; their mean age was 13.88±2.46 years, 38.46% were males, and 61.54% were females. Bilateral NCS of the sensory and motor lower limb nerves was performed using Medelec Synergy machine. Interpretation of the patients’ results was based on our own control reference values. Data was analysed using IBM SPSS statistics. Out of the 50 diabetic patients, 44 (88%) had electrophysiological evidence of peripheral neuropathy (abnormalities in at least two of the electrophysiological parameters). The majority (68.2%) had motor involvement and 31.8% had sensorimotor, while none of them (0%) had pure sensory involvement. Regarding abnormal NCS parameters (conduction velocity vs. amplitude of the compound action potential), conduction slowing feature predominated in 61.4% and only few (6.8%) showed amplitude reduction, while 31.8% showed mixed features. The most frequently affected nerve was the common peroneal, followed by posterior tibial, and the least was the sural nerve. The most sensitive parameter was the common peroneal conduction velocity. Motor precedes sensory nerve involvement. The most frequent neurophysiological abnormality was the conduction slowing, and the common peroneal was the most vulnerable nerve. These findings signify generation of a protocol for early screening of neuropathy in children with type 1 diabetes.
url http://dx.doi.org/10.1155/2019/2435261
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