Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cells.

Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cells.

<h4>Background</h4>The MAPK/ERK1/2 serine kinases are primary mediators of the Ras mitogenic signaling pathway. Phosphorylation by MEK activates MAPK/ERK in the cytoplasm, and phospho-ERK is thought to enter the nucleus readily to modulate transcription.<h4>Principal findings</h...

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Bibliographic Details
Main Authors: Elizabeth R Smith, Kathy Qi Cai, Jennifer L Smedberg, Melina M Ribeiro, Malgorzata E Rula, Carolyn Slater, Andrew K Godwin, Xiang-Xi Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20174585/pdf/?tool=EBI

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