mTORC1-dependent increase in oxidative metabolism in POMC neurons regulates food intake and action of leptin

mTORC1-dependent increase in oxidative metabolism in POMC neurons regulates food intake and action of leptin

Objective: Nutrient availability modulates reactive oxygen species (ROS) production in the hypothalamus. In turn, ROS regulate hypothalamic neuronal activity and feeding behavior. The mechanistic target of rapamycin complex 1 (mTORC1) pathway is an important cellular integrator of the action of nutr...

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Bibliographic Details
Main Authors: Magalie Haissaguerre, Amandine Ferrière, Vincent Simon, Nicolas Saucisse, Nathalie Dupuy, Caroline André, Samantha Clark, Omar Guzman-Quevedo, Antoine Tabarin, Daniela Cota
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877818302783

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