Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016

Vibeke Andersen, 1–3 Sören Möller, 4 Peter Bjødstrup Jensen, 4 Frederik Trier Møller, 5, 6 Anders Green 4 1Focused Research Unit for Molecular Diagnostic and Clinical Research (MOK), Hospital of Southern Jutland, Åbenrå DK-6200,...

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Main Authors: Andersen V, Möller S, Jensen PB, Møller FT, Green A
Format: Article
Language:English
Published: Dove Medical Press 2020-03-01
Series:Clinical Epidemiology
Subjects:
Online Access:https://www.dovepress.com/caesarean-delivery-and-risk-of-chronic-inflammatory-diseases-inflammat-peer-reviewed-article-CLEP
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spelling doaj-e42491ca4dc442448fa77db68ec738122020-11-24T21:45:06ZengDove Medical PressClinical Epidemiology1179-13492020-03-01Volume 1228729352368Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016Andersen VMöller SJensen PBMøller FTGreen AVibeke Andersen, 1–3 Sören Möller, 4 Peter Bjødstrup Jensen, 4 Frederik Trier Møller, 5, 6 Anders Green 4 1Focused Research Unit for Molecular Diagnostic and Clinical Research (MOK), Hospital of Southern Jutland, Åbenrå DK-6200, Denmark; 2Institute of Regional Research (IRS-Center Sonderjylland), University of Southern Denmark, Odense C DK-5000, Denmark; 3Institute of Molecular Medicine, University of Southern Denmark, Odense C DK-5000, Denmark; 4Open Patient data Explorative Network (OPEN), Department of Clinical Research, Odense University Hospital and University of Southern Denmark, Odense C DK-5000, Denmark; 5Department of Epidemiology Research, Statens Serum Institute, Copenhagen DK-2300, Denmark; 6Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institute, Copenhagen DK-2300, DenmarkCorrespondence: Vibeke Andersen Email va@rsyd.dkBackground: Chronic inflammatory diseases in childhood and early adult life share aetiological factors operating from birth and onwards. In this study, we use data from the national Danish health registers to evaluate the risk of developing four common, immune-mediated hospital-diagnosed childhood chronic inflammatory diseases.Methods: A national population-based registry study. Data from the Danish Medical Birth Registry and the Danish National Patient Registry from January 1973 to March 2016 were linked at a personal level to evaluate any potential associations between caesarean section and development of Inflammatory bowel diseases, rheumatoid arthritis, coeliac disease and diabetes mellitus among the offspring. A model adjusted for parental age at birth, decade of birth, gender of child, and parents’ chronic inflammatory disease status was used.Results: This register-based national cohort study of 2672708 children with information on delivery mode found an increased risk of diabetes, arthritis, coeliac disease, and inflammatory bowel disease for both girls and boys after caesarean section compared with vaginal delivery. The higher risk was present at least 40 years after delivery. In a subgroup analysis, both acute and elective caesarean section was associated with an increased risk of developing a chronic inflammatory disease.Conclusions: Being born by caesarean section leads to increased host susceptibility for chronic inflammatory diseases that last for decades. This finding should be further addressed in future studies with the aim to support the development of new strategies for prevention, treatment, and maybe even cure.Keywords: caesarean delivery, population study, vaginal birth, chronic inflammatory disease, inflammatory bowel diseases, rheumatoid arthritis, coeliac diseasehttps://www.dovepress.com/caesarean-delivery-and-risk-of-chronic-inflammatory-diseases-inflammat-peer-reviewed-article-CLEPcaesarean deliverypopulation studyvaginal birthchronic inflammatory diseaseinflammatory bowel diseasesrheumatoid arthritiscoeliac diseasediabetes mellitus
collection DOAJ
language English
format Article
sources DOAJ
author Andersen V
Möller S
Jensen PB
Møller FT
Green A
spellingShingle Andersen V
Möller S
Jensen PB
Møller FT
Green A
Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016
Clinical Epidemiology
caesarean delivery
population study
vaginal birth
chronic inflammatory disease
inflammatory bowel diseases
rheumatoid arthritis
coeliac disease
diabetes mellitus
author_facet Andersen V
Möller S
Jensen PB
Møller FT
Green A
author_sort Andersen V
title Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016
title_short Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016
title_full Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016
title_fullStr Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016
title_full_unstemmed Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016
title_sort caesarean delivery and risk of chronic inflammatory diseases (inflammatory bowel disease, rheumatoid arthritis, coeliac disease, and diabetes mellitus): a population based registry study of 2,699,479 births in denmark during 1973–2016
publisher Dove Medical Press
series Clinical Epidemiology
issn 1179-1349
publishDate 2020-03-01
description Vibeke Andersen, 1–3 Sören Möller, 4 Peter Bjødstrup Jensen, 4 Frederik Trier Møller, 5, 6 Anders Green 4 1Focused Research Unit for Molecular Diagnostic and Clinical Research (MOK), Hospital of Southern Jutland, Åbenrå DK-6200, Denmark; 2Institute of Regional Research (IRS-Center Sonderjylland), University of Southern Denmark, Odense C DK-5000, Denmark; 3Institute of Molecular Medicine, University of Southern Denmark, Odense C DK-5000, Denmark; 4Open Patient data Explorative Network (OPEN), Department of Clinical Research, Odense University Hospital and University of Southern Denmark, Odense C DK-5000, Denmark; 5Department of Epidemiology Research, Statens Serum Institute, Copenhagen DK-2300, Denmark; 6Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institute, Copenhagen DK-2300, DenmarkCorrespondence: Vibeke Andersen Email va@rsyd.dkBackground: Chronic inflammatory diseases in childhood and early adult life share aetiological factors operating from birth and onwards. In this study, we use data from the national Danish health registers to evaluate the risk of developing four common, immune-mediated hospital-diagnosed childhood chronic inflammatory diseases.Methods: A national population-based registry study. Data from the Danish Medical Birth Registry and the Danish National Patient Registry from January 1973 to March 2016 were linked at a personal level to evaluate any potential associations between caesarean section and development of Inflammatory bowel diseases, rheumatoid arthritis, coeliac disease and diabetes mellitus among the offspring. A model adjusted for parental age at birth, decade of birth, gender of child, and parents’ chronic inflammatory disease status was used.Results: This register-based national cohort study of 2672708 children with information on delivery mode found an increased risk of diabetes, arthritis, coeliac disease, and inflammatory bowel disease for both girls and boys after caesarean section compared with vaginal delivery. The higher risk was present at least 40 years after delivery. In a subgroup analysis, both acute and elective caesarean section was associated with an increased risk of developing a chronic inflammatory disease.Conclusions: Being born by caesarean section leads to increased host susceptibility for chronic inflammatory diseases that last for decades. This finding should be further addressed in future studies with the aim to support the development of new strategies for prevention, treatment, and maybe even cure.Keywords: caesarean delivery, population study, vaginal birth, chronic inflammatory disease, inflammatory bowel diseases, rheumatoid arthritis, coeliac disease
topic caesarean delivery
population study
vaginal birth
chronic inflammatory disease
inflammatory bowel diseases
rheumatoid arthritis
coeliac disease
diabetes mellitus
url https://www.dovepress.com/caesarean-delivery-and-risk-of-chronic-inflammatory-diseases-inflammat-peer-reviewed-article-CLEP
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