Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress

• Main Author: Joseph C. Sloop
• Format: Article
• Language: English
• Published: Hindawi Limited 2017-01-01
• Series: Journal of Chemistry
• Online Access: http://dx.doi.org/10.1155/2017/2860123

Heterocyclic molecules incorporating fluorinated isoquinoline components are found in many medicinally and agriculturally important bioactive products as well as industrially impactful materials. Within the past decade, a variety of isoquinolinic ring assembly techniques has enabled the introduction of diverse fluorine-containing functionalities which can enhance potential bioactivity and industrial utility. This review examines recent noncatalyzed and transition metal catalyzed synthetic approaches to the assembly of isoquinoline derivatives that are ring-fluorinated and/or result in the incorporation of fluorine-containing functional groups. Specifically, efficient synthetic methods and regioselectivity in the incorporation of functional groups into isoquinoline ring systems are examined.