Potential Anti-Alzheimer Agents from Guanidinyl Tryptophan Derivatives with Activities of Membrane Adhesion and Conformational Transition Inhibitions

Potential Anti-Alzheimer Agents from Guanidinyl Tryptophan Derivatives with Activities of Membrane Adhesion and Conformational Transition Inhibitions

Guanidinyl tryptophan derivatives TGN1, TGN2, TGN3, and TGN4 were synthesized, and these compounds were shown to possess in vitro inhibitory activity for amyloid aggregation in a previous study. Nevertheless, the influence of the TGN series of compounds on the binding and permeation behaviors of an...

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Bibliographic Details
Main Authors: Pathomwat Wongrattanakamon, Jutamas Jiaranaikulwanitch, Opa Vajragupta, Supat Jiranusornkul, Chalermpong Saenjum, Wipawadee Yooin
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
Aβ monomer
Alzheimer’s disease
guanidinyl tryptophan compounds
lipid bilayer
molecular dynamics simulation
TGN4
Online Access:https://www.mdpi.com/1420-3049/26/16/4863

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