A regulatory review for products containing glutathione

• Main Authors: Nur Hidayah Abd Rahim, Long Chiau Ming, Yaser Mohammed Ali Al-Worafi, Md Moklesur Rahman Sarker
• Format: Article
• Language: English
• Published: Archives of Global Professionals 2016-01-01
• Series: Archives of Pharmacy Practice
• Subjects: Antioxidant; efficacy; glutathione; health supplement; safety; regulation of healthcare products
• Online Access: http://www.archivepp.com/article.asp?issn=2045-080X;year=2016;volume=7;issue=5;spage=57;epage=60;aulast=Abd

Glutathione is a potent antioxidant as well as has important role for DNA synthesis and repair, protein synthesis, amino acid transport, and enzyme activation. Besides this, Glutathione products are now mainly selling as whitening agent which are mainly marketing through social media (Facebook) and different websites. Information is not available whether glutathione product are following the regulatory guidelines of National Pharmaceutical Control Bureau of Malaysia (NPCB) for selling, advertisement and promotion. This review was carried out by extracting information about glutathione from scientific database using PubMed, Cochrane Library and Embase. Analysis of the available information, case example of glutathione products showed that a brand of glutathione (Glutacaps HQ) did not show the product's registration number from NPCB, and also did not show the name, address, contact number of the advertiser, and even not found the name of the manufacture. Without providing the above mentioned information, the product is selling and promoting through social media (fb) which is not allowed by the NPCB guidelines part 4.14. So far, only two clinical trials were conducted on glutathione supplementation for 4 weeks duration. There was no serious or systematic adverse effects reported in clinical trials. As the two clinic trials resulted contradictory outcomes, further studies needed for conformation of the clinic benefits of glutathione. Otherwise, random use of glutathione may be risk for the health of the people. Besides, the marketer mainly promoting glutathione as the skin whitening beauty product instead of using as health supplement, it may cause additional and serious risk to the users as the manufacturer not providing sufficient information about the product, its registration number, manufacturing company, etc.